representation of an antibody documented in a bioregistry

What Is a Bioregistry?

A bioregistry is a structured data repository that helps scientists answer a multitude of questions during the biotherapeutic development process.

It can be on it’s own, but it is more effective as a feature of broader antibody discovery software.

By efficiently attaining answers to those questions scientists can make data-driven decisions, increase efficiency, and trust the integrity of their data. Time is precious in biotherapeutic development and reducing duplicative efforts and time wasted in finding entity information can be highly advantageous to most organizations. 

From cell lines and constructs to their vectors and insert sequences, biotherapeutic development involves many moving parts that need to be defined and connected. Using spreadsheets to manage this data and their inter-relationships is a highly inefficient and error-prone endeavor. Without a central bioregistry to capture and track all of these pieces, researchers could end up with data that is inaccurate, redundant, and insufficient. 

Adopting a bioregistry can provide biopharma organizations with the following benefits:

  • Centralization of information for critical biological entities and protection of intellectual property
  • Eliminating duplication and improving data integrity by verifying the uniqueness of entities upon registration
  • Creation of links between samples, entities, electronic lab notebooks and entity creation processes (protein, expression, purification, characterization)

Spreadsheets vs. a Bioregistry

Most teams start tracking biological entities in spreadsheets. The gaps show up as the number of entities and the number of people touching them grows.

Spreadsheets Bioregistry
Finding an entity Search across files and tabs, then check you opened the latest version One searchable record per entity
Duplicates Caught by manual checks, if at all Uniqueness verified at registration
Relationships Cell lines, vectors, and insert sequences linked by hand across tabs Connected records researchers can navigate
Samples and assay data Stored separately from the entity they came from Linked to the entity, so a molecule leads to its sequences, samples, and assay data
Intellectual property Spread across personal drives and shared folders Centralized in one place

A true bioregistry is a feature of purpose-built biologics informatics software. The main platforms that offer one are LabKey (in Biologics LIMS), Benchling, Dotmatics (Bioregister), and BIOVIA Biological Registration. Each handles the same core job: registering biological entities, verifying their uniqueness, and connecting them to their sequences, samples, and assay data.

LabKey Biologics LIMS Bioregistry

Biologics LIMS includes a fully integrated bioregistry as part of a suite of integrated software tools for biotherapeutic development. The bioregistry captures complete entity and sample information for molecular entities, nucleotide sequences, protein sequences, expression systems, constructs, vectors and cell lines. Researchers can easily navigate through entities and their relationships. For example, researchers can find a specific molecule and see the component sequences, the samples of that molecule and the assay data associated with those samples.

Click Here to learn more about LabKey Biologics LIMS and take a tour!

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