LabKey Supports for NIAID COVID-19 Immune Response Consortium

Since the start of the COVID-19 pandemic, the urgent need to gather, harmonize and share data has been felt across the scientific research community. To meet this demand, the NIAID Immune Response Consortium developed the HGRepo Informatics Framework in partnership with LabKey. This informatics system centralizes unstructured and de-identified clinical data collected from 14 domestic and international hospital sites. Researchers are using this data to study host genetics, host response, and microbial genetics as they relate to COVID-19. Downstream data from their research includes gene expression data, single-cell multi-omics data, humoral signature data, serology and more. 

Support from LabKey

LabKey supports NIAID by providing a platform to link all of the generated data back to the original clinical, demographics, and phenotype data. By helping integrate, track and make data accessible for collaborative research and integrated analysis, LabKey is helping researchers to quickly get the most insight from the consortium research data. In short, LabKey Server provided a central data repository to provide standardization and structure to clinical data including:

  • Definition of Dataset and Sample Properties
  • Controlled Vocabularies 
  • Categorical Data Groupings
  • Reports and Views
  • Automated update of links to Assay Data
  • Calculated timeline durations for samples
  • NIH SAML Authentication
  • Folder & Role Permissions

Watch the HGRepo Presentation at LKUC 2020

At the 2020 LabKey User Conference,  Sandhya Xirasagar Ph.D., Lead, Clinical and Laboratory Informatics Section with NIAID and  Jason Barnett, Contract Lead, Medical Science and Computing, Inc. presented on the HGRepo Informatics Framework. Their presentation covers the informatics framework including the background and requirements for the scientific data management system, a demo of HGRepo and the future vision for the system. Watch below: