In late 2015, Genomics England began working with LabKey to develop a LabKey Server-based data management and exploration portal that would facilitate the knowledge sharing dialogue between clinicians and researchers as part of the UK’s 100,000 Genomes Project.
The 100,000 Genomes Project, as characterized by Genomics England’s Chief Technology Officer, Jim Davies, is intended to promote “a dialogue between the clinical context and researchers.” This project, the largest national sequencing project of its kind in the world, will give both clinicians and researchers access to an unprecedented depth of data and information through the sequencing of 100,000 genomes from approximately 70,000 people including patients with a rare disease and their families, as well as patients with cancer. The mission of this dialogue is to ultimately bring benefit to patients and to enable new scientific discovery and medical insights in an ethical and transparent manner that will promote the development of a UK genomics industry.
The first phase of this collaboration centered around providing clinicians and researchers access to centralized phenotypic and sample information gathered from sites across the UK while ensuring security and privacy of patient information. The LabKey team focused development efforts during phase 1 on the aggregation, review, and integration of phenotype and genotype information from cancer and rare disease patient data.
This phase has provided:
- Secure, extensible and reliable pipelines for data collection from 13 NHS Genomic Medicine Centres leading participant recruitment and partnering hospitals & clinics
- Medical review workflow to assess data gathered of participants and families
- Web portals for secure access of data
- LabKey Server’s built-in reporting, querying, and visualization tools
LabKey and Genomics England are bringing the value of dialogue to the development process. LabKey is excited to continue its tradition of collaborating closely with its partners. With Genomics England, LabKey has developed a deep shared understanding of goals leading to a phased development roadmap of the LabKey Server platform. Close communication and collaboration will enable LabKey to flexibly accommodate new requirements and priority shifts to ensure a high-quality final product.
LabKey looks forward to the next phase of development of a “research” LabKey Server platform that will securely store and enable access to de-identified information that can be used by clinicians and researchers for advanced analysis. LabKey is proud to support Genomics England’s mission to promote a productive “dialogue” that will improve patient outcomes and scientific progress.
To learn more about the 100,000 Genomes Project, visit: https://www.genomicsengland.co.uk/the-100000-genomes-project/